Thousand Oaks Injectable Fillers for Wrinkles

Restylane – Hydrelle – Perlane – Juvederm Ultra & Ultra Plus

They contain Hyaluronic acid which is a substance present in all human beings. The hyaluronic acid is in the form of a crystal-clear gel injected into the skin to augment the lip volume and soften a wrinkle or a fold.

  • Perlane and Juvederm Ultra Plus have a larger particle size than Restylane, Hydrelle and Juvederm Ultra and are used for the deep folds and wrinkles of the face
  • They work in skin by combining with the water in your tissue to create volume, thereby, plumping up the cells and creating a more youthful and healthy appearance
  • Once in the skin, they work together with the body’s own hyaluronic acid and join forces to create volume
  • These fillers can last anywhere from 4-12 months. After the first injection a touch-up in 2-4 weeks may be necessary
  • Injections are usually put into the frown lines, lines around the mouth (nasolabial folds and marionette lines), to fill the lip for more fullness and into the lip lines
  • Restylane, Perlane, Hydrelle,Juvederm Ultra and Ultra Plus are used for filling lines that are seen when your facial muscles are relaxed
  • If you are trying to prevent the wrinkles from appearing with motion or to prevent wrinkles from deepening, then Botox® should be used instead or in combination with Restylane, Perlane, Hydrelle, Juvederm Ultra and Ultra Plus
  • Restylane, Perlane, Hydrelle and Juvederm can be used without local anesthesia, but it is most common to do a small nerve block around the mouth to lessen the pain of injection
  • Restylane was the first of these products to be developed and has been safely used in Europe for many years
  • Hydrelle is Hyaluronic acid with 0.3% Lidocaine added to ease the pain of injection
  • Restylane, Juvederm, Hydrelle and Perlane do not have to be tested for allergies
  • You shouldn’t apply excessive heat or excessive massage to the area for about a week as this may breakdown the fillers more rapidly
  • After the injection you may see some redness or swelling for 2-3 days

Other trade names for hyaluronic acid Captique, Hylaform and Hylaform Plus


Collagen is derived either from a bovine source or from a human source

  • Zyderm or Zyplast is from a bovine source
  • Cymetra, Cosmoderm, Cosmoplast, Autologen, Fascian are from a human source
  • These fillers are more difficult to process and inject into the wrinkles or suffer from the fact that a skin test may have to be performed first to test for allergies

Radiesse (formerly called Radiance)

Semi-Permanent filler made up of Calcium hydroxyl-apatite (a substance found in bone and teeth, made into an injectable paste)

  • Can last 2-5 years and works by your own collagen forming around the micro-spheres
  • Problems encountered – Similar in many respects to all semi-permanent fillers with clumping, lumping, granulomas and micro-spheres that may move to other areas of the body
  • If injected next to bone, formation of bone can occur, which also can be advantageous in certain situations


Synthetic polylactic acid contained in micro-spheres

  • Restores volume in the face and has been used in HIV patients


A permanent filler which is not allowed for use in the USA as an injectable

  • Although an excellent injectable filler when injected in small amounts, larger amounts form granulomas and adherent lumps to the skin which can eventually become noticeable

For a Restylane or Juvederm Filler Injection from Dr. Costanzo of Thousand Oaks call: (805) 373-9919