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Injectable Fillers for Wrinkles
Restylane - Perlane - Hydrelle - Juvederm - Radiesse

"Fight the Signs of Aging"

Restylane, Perlane, Hydrelle, Juvederm, Radiesse, ArteFill are Injectable Soft Tissue Fillers for Facial Wrinkles, such as Nasolabial Folds and Lines in the Lip, Mouth, Forehead.  Soften the Marionette and Frown Lines, get bigger lips and fill in the cheeks by visiting Chris Costanzo, MD

Restylane - Hydrelle - Perlane - Juvederm Ultra & Ultra Plus

They contain Hyaluronic acid which is a substance present in all human beings.  The hyaluronic acid is in the form of a crystal-clear gel injected into the skin to augment the lip volume and soften a wrinkle or a fold. 

  • Perlane and Juvederm Ultra Plus have a larger particle size than Restylane, Hydrelle and Juvederm Ultra and are used for the deep folds and wrinkles of the face

  • They work in skin by combining with the water in your tissue to create volume,  thereby, plumping up the cells and creating a more youthful and healthy appearance

  • Once in the skin, they work together with the body's own hyaluronic acid and join forces to create volume

  • These fillers can last anywhere from 4-12 months.  After the first injection a touch-up in 2-4 weeks may be necessary

  • Injections are usually put into the frown lines, lines around the mouth (nasolabial folds and marionette lines), to fill the lip for more fullness and into the lip lines

  • Restylane, Perlane, Hydrelle,Juvederm Ultra and Ultra Plus are used for filling lines that are seen when your facial muscles are relaxed

  • If you are trying to prevent the wrinkles from appearing with motion or to prevent wrinkles from deepening, then Botox┬« should be used instead or in combination with Restylane, Perlane, Hydrelle, Juvederm Ultra and Ultra Plus

  • Restylane, Perlane, Hydrelle and Juvederm can be used without local anesthesia, but it is most common to do a small nerve block around the mouth to lessen the pain of injection

  • Restylane was the first of these products to be developed and has been safely used in Europe for many years

  • Hydrelle is Hyaluronic acid with 0.3% Lidocaine added to ease the pain of injection

  • Restylane, Juvederm, Hydrelle and Perlane do not have to be tested for allergies

  • You shouldn't apply excessive heat or excessive massage to the area for about a week as this may breakdown the fillers more rapidly

  • After the injection you may see some redness or swelling for 2-3 days

Other trade names for hyaluronic acid Captique, Hylaform and Hylaform Plus


Collagen is derived either from a bovine source or from a human source

  • Zyderm or Zyplast is from a bovine source

  • Cymetra, Cosmoderm, Cosmoplast, Autologen, Fascian are from a human source

  • These fillers are more difficult to process and inject into the wrinkles or suffer from the fact that a skin test may have to be performed first to test for allergies

Radiesse (formerly called Radiance)

Semi-Permanent filler made up of Calcium hydroxyl-apatite (a substance found in bone and teeth, made into an injectable paste)

  • Can last 2-5 years and works by your own collagen forming around the micro-spheres

  • Problems encountered - Similar in many respects to all semi-permanent fillers with clumping, lumping, granulomas and micro-spheres that may move to other areas of the body

  • If injected next to bone, formation of bone can occur, which also can be advantageous in certain situations


Synthetic polylactic acid contained in micro-spheres


A permanent filler which is not allowed for use in the USA as an injectable

For a Restylane or Juvederm Filler Injection
from Dr. Costanzo of Thousand Oaks


This Board Certified Plastic Surgeon
805 / 373-9919

Get Restylane, Perlane, Juvederm, Hydrelle, Radiesse, Chemical Peels, Laser and Wrinkle treatment from Dr. Costanzo of Thousand Oaks, a Board Certified Plastic Surgeon, specializing in Cosmetic Surgery, serving all of Southern California including Thousand Oaks, Beverly Hills, Los Angeles, Encino, Woodland Hills, Tarzana, Sherman Oaks, Calabasas, Chatsworth, Granada Hills, Ventura, Agoura, Westlake Village, Moorpark, Simi Valley, Santa Barbara, Oxnard, San Diego, Riverside County and Orange County

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Disclaimer - The information about Cosmetic surgery contained in this web site is for
informational purposes only and does not constitute medical advice.
Call to schedule an appointment with Thousand Oaks Plastic surgeon Dr. Costanzo,
2190 Lynn Road, Suite 380, Thousand Oaks, CA 91360